Osteocytes as Mechno-senor for Bone
讲座名称：
Osteocytes as Mechno-senor for Bone
讲座时间：
2009-08-03
讲座人：
郭向东
形式：
校区：
兴庆校区
实践学分：
讲座内容：
It has been accepted that bone adapts to changes in the mechanical environment, the mechanisms by which bone cells detect or respond to these changes is still unclear. It is well recognized that the mature bone cells, osteocytes embedded in the lacunae can sense mechanical stimulation in bone tissue and transfer these signals to bone forming osteoblasts, which can secret organic matrix to form new bone tissue. Osteocytes forms extensive intercellular processes with each other as well as with osteoblasts via gap junctions. In many aspects, the osteocytes form elaborate network similar to neuronal network. Using in vitro three-dimensional explant model and two-dimensional bone cell network model, we have examined the roles of osteocytes in sensing mechanical loads and its regulation of bone formation via osteocyte-osteoblasts communication. In addition, the network features of osteocytes under mechanical loading were examined and the underlying biochemical pathways have been examined. These results provide novel observations of osteocytes as the key mechanosenor.
相关视频