Progress and challenges in axial transmission measurements of guided modes in cortical bone: From lab experiments to clinics
讲座名称：
Progress and challenges in axial transmission measurements of guided modes in cortical bone: From lab experiments to clinics
讲座时间：
2017-05-18
讲座人：
Minonzio Jean-Gabriel
形式：
校区：
兴庆校区
实践学分：
讲座内容：
讲座名称：Progress and challenges in axial transmission measurements of guided modes in cortical bone: From lab experiments to clinics
讲座时间：5月18日 下午15:00-16:00
讲座地点：曲江科技园 西五楼 A228（北楼二楼东侧）
讲座学者：Minonzio Jean-Gabriel 博士
Cortical bone porosity has been evidenced as being a major if not the major `footprint' of bone loss and fragility. Several studies report that cortical bone behaves like a waveguide. Measurements of guided mode wavenumbers together with appropriate waveguide modeling have therefore the potential for providing estimations of effective stiffness coefficients (which are largely determined by cortical porosity) and also cortical thickness. However, data interpretation is challenging due to the heterogeneous, dissipative and irregular nature of the wave guide. Moreover surrounding and internal tissues modify the guided modes. This paper presents current progress, made by the Laboratory of Biomedical Imaging (LIB, UPMC, Paris) and the spin-off company Azalée, in the measurement of the wavenumbers of guided wave modes, using a multi-transmitter multi-receiver axial transmission probe. The guided mode wavenumbers are obtained after projection of test vectors onto the basis of the singular vectors of the transfer response matrix, at each frequency. The SVD-based method has been validated, first on isotropic elastic and visco-elastic plates, then on bone-mimicking plate and tube phantoms made of transverse isotropic absorbing material. The effect of soft-tissue mimicking layers on top of a bone mimicking phantom has also been studied. Finally, ex vivo validation on human radius and first clinics finding obtained using the approach will be presented.
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