2014诺贝尔奖得主西安交大校园行讲座(三)
讲座名称：
2014诺贝尔奖得主西安交大校园行讲座(三)
讲座时间：
2014-09-18
讲座人：
铃木章
形式：
校区：
兴庆校区
实践学分：
讲座内容：
2014诺贝尔奖得主西安交大校园行讲座(三)
讲座名称：Cross-Coupling Reactions of Organoboranes: An Easy Way for Carbon-Carbon Bonding
讲座时间：2014年9月18日下午4:00-5:00
讲座地点：科学馆101报告厅
讲座人：2010诺贝尔化学奖得主铃木章Akira Suzuki
讲座内容：
The palladium-catalyzed cross-coupling reaction between different types of organoboron compounds and various organic halides or triflates in the presence of base provides a powerful and general methodology for the formation of carbon-carbon bonds. The (sp3)C-B compounds (alkylboron compounds) and (sp2)C-B compounds (such as aryl- and 1-alkenylboron derivatives) readily cross-couple with organic electrophiles to give coupled products selectively in high yields. Recently, the (sp)C-B compounds (1-alkynylboron derivatives) have been also observed to react with organic electrophiles to produce expected cross-coupled products.
Such coupling reactions offer several advantages:
(1) ready availability of reactants
(2) mild reaction conditions
(3) water stability
(4) easy use of the reaction both in aqueous and heterogeneous conditions
(5) toleration of a broad range of functional groups
(6) highregio- and stereoselectivity of the reaction
(7) insignificant effect of steric hindrance
(8) use of a small amount of catalysts
(9) application in one-pot synthesis
(10) nontoxic reaction
(11) easy separation of inorganic boron compound
(12) green chemistry
These coupling reactions have been actively utilized not only in academic laboratories but also in industrial processes including pharmaceutical and agrochemical industries, and liquid crystal and OELD production.
In this lecture, the overview of the coupling reaction will be discussed to understand the whole.
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