Nanotechnology for Drug Delivery and Tissue Engineering
讲座名称：
Nanotechnology for Drug Delivery and Tissue Engineering
讲座时间：
2014-07-07
讲座人：
许巧兵
形式：
校区：
兴庆校区
实践学分：
讲座内容：
题目：Nanotechnology for Drug Delivery and Tissue Engineering
报告人：许巧兵
时间：7月7日周一，上午9：00
地点：材料学院205会议室
Abstract:
Biomaterials at nanoscale have been widely studied as novel vectors for controlled drug delivery and artificial matrices for tissue engineering. In my group, we are interested in developing micro/nanotechnology for biomedical applications, including nanomedicine and tissue engineering. In the first part of my presentation, I will talk about the development of a combinatorial library of lipid-like materials and their applications as non-viral vectors for the intracellular delivery of various biomacromolecules, including DNA, mRNA and proteins for cancer therapy. From the library screening, we attempted to build a correlation between the chemical structures of the delivery vectors and their efficiency in biomacromolecule delivery, which will be useful for the rational design of novel delivery systems. In the second part of my talk, I will present a novel technique, called “Bioskiving” that we recently developed to fabricate novel tissue constructs from decellularized biological tissues. For example, we fabricated various 2D and 3D constructs from a piece of decelullarized tendon which comprises of bundles of well aligned collagen nanofibers using a combination of tissue sectioning, stacking and rolling. We have further extended this strategy to other decellularized tissues. Some potential biomedical applications, such as nerve conduits and blood vessels, of this novel fabrication strategy will be discussed.
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