Metalloradical Catalysis for Stereoselective Organic Synthesis
讲座名称：
Metalloradical Catalysis for Stereoselective Organic Synthesis
讲座时间：
2013-07-23
讲座人：
X. Peter Zhang
形式：
校区：
兴庆校区
实践学分：
讲座内容：
讲座名称：Metalloradical Catalysis for Stereoselective Organic Synthesis
讲座时间：2013-7-23（周二）,15:00
讲座地点：科学馆207（地点如有变动，会另行通知）
讲座人：X. Peter Zhang，Department of Chemistry, University of South Florida, Tampa, FL 33620
讲座内容：Organic synthesis has been dominated by chemical reactions that are based on 2e processes, either stoichiometrically or in catalytic fashion. While 1e radical chemistry is equally rich, its application in organic synthesis has been hampered by several enduring challenges. Over the past decade, we have been in the process of formulating metalloradical catalysis (MRC) as a powerful new concept for controlling both reactivity and stereoselectivity of radical reactions as well as for catalytic generation of carbon- and nitrogen-based radicals from common organic precursors. For achieving enantioselective radical reactions via MRC, we have developed a family of unique chiral metalloradical catalysts based on structurally well-defined Co(II) complexes of D2-symmetric chiral porphyrins with tunable electronic, steric, and chiral environments. These Co(II)-based metalloradical catalysts have been shown to be highly effective for a wide range of stereoselective carbene and nitrene transfer reactions, including alkene cyclopropanation, alkene aziridination, C–H alkylation and C–H amination. Due to their distinctive radical mechanisms that involve unprecedented metallocarbene and metallonitrene radical intermediates, the Co(II)-based metalloradical systems enable addressing some long-standing problems in these important organic transformations.
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