Nano and Microscale Engineering of Three-Dimensional (3D) Cell and Tissue Microenvironment
讲座名称：
Nano and Microscale Engineering of Three-Dimensional (3D) Cell and Tissue Microenvironment
讲座时间：
2009-12-24
讲座人：
Feng Xu
形式：
校区：
兴庆校区
实践学分：
讲座内容：
Abstract: We are interested in creating three-dimensional (3D) cell and tissue microenvironments which mimic the conditions of native tissues. Using today’s micro and nanoscale technologies (e.g., micro and nanofluidics, lithographic approaches and micromolding technologies), creating such synthetic but native-like conditions are the prerequisites for understanding the cell behavior (e.g., transformation of normal cells to cancerous ones). Most research involving human cell manipulation has been carried out on artificial two-dimensional (2D) substrates. However, recent studies showed that cells respond and behave substantially different in these 2D settings compared to in 3D intricate microenvironment that cells reside in. Now, it is within our reach to grow and manipulate cells in tissue-like environments, given the current state-of-the-art technologies. These cell and tissue culture constructs present a tissue-like architecture for growing cells at tissue densities (cell to cell distances). Therefore, innovative 3D in vitro cellular models with precisely patterned multiple types of cells are needed for re-creating distinct niches and in vitro cell modeling under well-defined and reproducible conditions (e.g., for cancer cell and stem cell). In this talk, I will present the '3D nano and microscale tissue engineering methods' we are developing and their applications in tissue engineering, cancer biology, stem cell niche, cell-based biosensor, and high throughput drug screening.
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