Curiosity Driven New Reactivity Discovery
讲座名称：
Curiosity Driven New Reactivity Discovery
讲座时间：
2018-06-11
讲座人：
史晓东
形式：
校区：
兴庆校区
实践学分：
讲座内容：
讲座名称：Curiosity Driven New Reactivity Discovery
讲座时间：2018年6月11日（星期一），上午11:10
讲座地点：西二楼A102，曲江校区
讲座人：史晓东博士
讲座内容：Homogeneous gold catalysis has been developed explosively during the past decades. Despite the remarkable electrophilic activation of alkynes by cationic Au(I) catalysts, such as PPh3Au+, one challenge is to overcome their poor stability at high temperature. However, in order to activate some less reactive substrates, such as internal alkynes, harsher reaction conditions are usually required.
As a good σ-donor and π-receptor, triazole has been applied as a ligand to improve the stability of cationic Au(I) catalysts. Taking advantage of the good stability of triazole-Au(I) complexes (TA-Au), we successfully achieved good reactivity of intermolecular hydroamination for both terminal and internal alkynes. Unlike previous reported gold catalysts, the TA-Au catalysts activate alkynes selectively over allenes. With this excellent chemoselectivity, TA-Au catalysts showed interesting reactivity in propargyl ester and vinyl ether rearrangement. This facilitates the development of otherwise challenging transformations, for instance, asymmetric synthesis of substituted allenes, Schmittel cyclization, dienal synthesis, and so on.
主办单位：前沿科学技术研究院
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