Adaptive Group Sequential Design Methods for Clinical Trials

讲座名称: Adaptive Group Sequential Design Methods for Clinical Trials
讲座时间: 2018-06-05
讲座人: Yi Cheng
形式:
校区: 兴庆校区
实践学分:
讲座内容: 报告题目:Adaptive Group Sequential Design Methods for Clinical Trials 报告时间:2018年6月5日,星期二,下午16:00-17:00 报告地点:数学与统计学院北五楼319会议室 报告人:程怡教授,美国Indiana University South Bend数学科学系 报告摘要: The presentation includes two parts. The first part is a brief introduction of adaptive group sequential designs in clinical trials. The second part presents a specific adaptive design, namely, Bayesian group sequential designs, summarized as follows. A clinical trial requires decisions about how an experiment will be conducted. The process is often dynamic; therefore, Bayesian formulation provides a powerful mechanism for running such a process. The decision theoretical approach considers the consequences of each possible designing parameter and selects ones to maximize the expected utility.  While utility setting and statistical decisions depend on the goals of the experiment, certain choices may be restricted by available resources and ethical considerations.  The Bayesian adaptive group sequential designs also have the flexibility of allowing interpretation of the results along frequentist lines, in addition to maximize the utility function. The frequentist error rates can be established so that the desired properties can be maintained for regulatory settings.
相关视频