Microfluidic microcapsule fabrication by interfacial complexation of polymers, particles and proteins
讲座名称：
Microfluidic microcapsule fabrication by interfacial complexation of polymers, particles and proteins
讲座时间：
2017-11-08
讲座人：
Chinedum Osuji
形式：
校区：
兴庆校区
实践学分：
讲座内容：
报告题目：Microfluidic microcapsule fabrication by interfacial complexation of polymers, particles and proteins
报告时间：2017年10月8日 周三 上午 10:00-12:00
报告地点： 仲英楼 B-253
报告人：Chinedum Osuji （耶鲁大学化学与环境工程系）
报告内容：
Microcapsules are generally spherical, hollow objects with thin, solid-like surfaces or shells. They have been aggressively pursued as designed chemical constructs for biomedical and other applications which most often seek to exploit their cargo-carrying, and cargo-releasing capability. Interfacial complexation provides a facile, rapid approach for microcapsule fabrication, and is amenable to the use of a wide variety of materials. It involves the formation of a solid-like shell due to the complexation of conjugate species at the interface of an emulsion droplet. Here we describe the use of interfacial complexation with microfluidic-generated droplets to fabricate a wide variety of monodisperse microcapsules involving polymers, particles and proteins as components of microcapsule shells. A diverse range of mechanical and release properties can be accessed depending on the specific composition of the shell layer. In particular we discuss: 1) the formation of highly stiff, yet elastic shells due to the incorporation of high-modulus cellulose nanofibrils; 2) the development of robust and modularly functionalizable microcapsules using engineered globular proteins with Janus-type characteristics, specifically, the bacterial hydrophobin BslA; 3) fabrication and optically triggered release behavior of microcapsules consisting of cross-linked graphene oxide nanosheets, with IR-photothermal responsivity. The relevance of the properties of these microcapsules to various applications is highlighted.
相关视频