Physiology and pathology of single live human bladder cancer cells stimulated with heavy metal ions

讲座名称: Physiology and pathology of single live human bladder cancer cells stimulated with heavy metal ions
讲座时间 2017-04-21
讲座地点 生命学院(教2楼)308学术报告厅
讲座人 Zhifeng Ding
讲座内容

应生命学院徐峰教授邀请,加拿大西安大略大学Zhifeng Ding教授来我院做学术交流。

 

报告题目: Physiology and pathology of single live human bladder cancer cells stimulated with heavy metal ions
报告人:Zhifeng Ding教授
报告时间: 2017年4月21日(星期五)下午16:30
报告地点:生命学院(教2楼)308学术报告厅
报告摘要:
Heavy metal ions are believed to be essential in trace amounts and toxic at acute concentrations. With scanning electrochemical microscopy (SECM)1, we quantitatively investigate time course alteration in the membrane permeability of single human bladder cancer cells (T24) to probing molecules ferrocenemethanol and ferrocencecaboxylic acid that is induced by heavy metal ions such as Cd2+,  Cr3+, Zn2+. The passive transport of th probing molecules reflects the integrity and the structural function of the cellular membranes. Quantification of the membrane permeability requires fitting the experimental probe approach curves (PACs) to the simulated ones. Time-lapse SECM depth scan technique was introduced to obtain the time-lapse PACs while monitoring the cell topography in real time. The induced penetration of T24 cell might be a one-step action.

 

 

 

讲座人介绍

Prof. Zhifeng Ding is a full professor of chemistry at the University of Western Ontario, Canada. He got Ph.D. in physical and analytical electrochemistry in the Girault group at Swiss Federal Institute of Technology in Lausanne (EPFL). His research focuses on scanning electrochemical microscopy, ionic liquids as novel electrolytes, electrochemiluminescence and solar cells. He has published more than 130 papers and received several awards: Premier’s Research Excellence Award 2003; Western Science Distinguished Research Professor 2014-2015; Western University Faculty Scholar 2015-2016; 2017 Canadian Society for Chemistry W.A.E. McBryde Medal.

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