Physiology and pathology of single live human bladder cancer cells stimulated with heavy metal ions
|讲座名称：||Physiology and pathology of single live human bladder cancer cells stimulated with heavy metal ions|
报告题目: Physiology and pathology of single live human bladder cancer cells stimulated with heavy metal ions
Heavy metal ions are believed to be essential in trace amounts and toxic at acute concentrations. With scanning electrochemical microscopy (SECM)1, we quantitatively investigate time course alteration in the membrane permeability of single human bladder cancer cells (T24) to probing molecules ferrocenemethanol and ferrocencecaboxylic acid that is induced by heavy metal ions such as Cd2+, Cr3+, Zn2+. The passive transport of th probing molecules reflects the integrity and the structural function of the cellular membranes. Quantification of the membrane permeability requires fitting the experimental probe approach curves (PACs) to the simulated ones. Time-lapse SECM depth scan technique was introduced to obtain the time-lapse PACs while monitoring the cell topography in real time. The induced penetration of T24 cell might be a one-step action.
Prof. Zhifeng Ding is a full professor of chemistry at the University of Western Ontario, Canada. He got Ph.D. in physical and analytical electrochemistry in the Girault group at Swiss Federal Institute of Technology in Lausanne (EPFL). His research focuses on scanning electrochemical microscopy, ionic liquids as novel electrolytes, electrochemiluminescence and solar cells. He has published more than 130 papers and received several awards: Premier’s Research Excellence Award 2003; Western Science Distinguished Research Professor 2014-2015; Western University Faculty Scholar 2015-2016; 2017 Canadian Society for Chemistry W.A.E. McBryde Medal.
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